Circadian variation in urinary excretion of bone collagen cross-links.
Identifieur interne : 000607 ( Main/Exploration ); précédent : 000606; suivant : 000608Circadian variation in urinary excretion of bone collagen cross-links.
Auteurs : A M Bollen [États-Unis] ; M D Martin ; B G Leroux ; D R EyreSource :
- Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research [ 0884-0431 ] ; 1995.
Descripteurs français
- KwdFr :
- Adulte (MeSH), Adulte d'âge moyen (MeSH), Collagène (urine), Collagène de type I (MeSH), Créatinine (urine), Dosage immunologique (MeSH), Femelle (MeSH), Humains (MeSH), Mâle (MeSH), Peptides (urine), Rythme circadien (MeSH), Résorption osseuse (diagnostic), Résorption osseuse (urine), Sujet âgé (MeSH).
- MESH :
- diagnostic : Résorption osseuse.
- urine : Adulte, Adulte d'âge moyen, Collagène, Collagène de type I, Créatinine, Dosage immunologique, Femelle, Humains, Mâle, Peptides, Rythme circadien, Résorption osseuse, Sujet âgé.
English descriptors
- KwdEn :
- MESH :
- chemical , urine : Collagen, Creatinine, Peptides.
- diagnosis : Bone Resorption.
- urine : Bone Resorption.
- Adult, Aged, Circadian Rhythm, Collagen Type I, Female, Humans, Immunoassay, Male, Middle Aged.
Abstract
Bone resorption can be evaluated by measuring the urinary excretion of collagen type I cross-linked N telopeptides (NTx). Since it is difficult to obtain (and verify) 24 h urine collections from patients, untimed spot urines are more practical. Such measurements, however, need correction for urine dilution and potentially may vary with collection time since a circadian rhythm in bone metabolism has been reported. This study examined cross-link excretion in urine voids serially collected during a 24 h period from subjects living their normal daily routine (as opposed to a controlled hospital setting). This mimics the situation for walk-in patients visiting a clinician and providing a spot urine. A total of 35 dentists (20 males, 15 females) collected all urine voids separately over a 24 h period. Urines were analyzed for creatinine and NTx. The effects of time of day on the excretion rates of these metabolites (in nmol/h) and on the cross-link:creatinine ratio were assessed. A circadian rhythm was evident in the excretion rate of creatinine with a peak in the late afternoon (18% higher than the 24 h mean, p = 0.0004). The NTx excretion rate peaked in the morning (9% higher than the 24 h mean) but this latter rhythm was not statistically significant (p = 0.31). The NTx:creatinine ratio fell during the day from a high (122% of the 24 h mean) in the early morning to a low in the early evening. This rhythm in the NTx:creatinine ratio in untimed spot urines was statistically significant (p < 0.0001). In conclusion, the NTx:creatinine ratio in spot urines from adult outpatient subjects showed a significant circadian rhythm. Variations in creatinine excretion were the primary cause. Time of day should, therefore, be taken into account when comparing test results of spot urines with normal ranges or with other samples from the same subject.
DOI: 10.1002/jbmr.5650101207
PubMed: 8619368
Affiliations:
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<record><TEI><teiHeader><fileDesc><titleStmt><title xml:lang="en">Circadian variation in urinary excretion of bone collagen cross-links.</title><author><name sortKey="Bollen, A M" sort="Bollen, A M" uniqKey="Bollen A" first="A M" last="Bollen">A M Bollen</name><affiliation wicri:level="4"><nlm:affiliation>Department of orthopaedics, University of Washington, Seattle, USA.</nlm:affiliation><country xml:lang="fr">États-Unis</country><wicri:regionArea>Department of orthopaedics, University of Washington, Seattle</wicri:regionArea><orgName type="university">Université de Washington</orgName><placeName><settlement type="city">Seattle</settlement><region type="state">Washington (État)</region></placeName></affiliation></author><author><name sortKey="Martin, M D" sort="Martin, M D" uniqKey="Martin M" first="M D" last="Martin">M D Martin</name></author><author><name sortKey="Leroux, B G" sort="Leroux, B G" uniqKey="Leroux B" first="B G" last="Leroux">B G Leroux</name></author><author><name sortKey="Eyre, D R" sort="Eyre, D R" uniqKey="Eyre D" first="D R" last="Eyre">D R Eyre</name></author></titleStmt><publicationStmt><idno type="wicri:source">PubMed</idno><date when="1995">1995</date><idno type="RBID">pubmed:8619368</idno><idno type="pmid">8619368</idno><idno type="doi">10.1002/jbmr.5650101207</idno><idno type="wicri:Area/Main/Corpus">000599</idno><idno type="wicri:explorRef" wicri:stream="Main" wicri:step="Corpus" wicri:corpus="PubMed">000599</idno><idno type="wicri:Area/Main/Curation">000599</idno><idno type="wicri:explorRef" wicri:stream="Main" wicri:step="Curation">000599</idno><idno type="wicri:Area/Main/Exploration">000599</idno></publicationStmt><sourceDesc><biblStruct><analytic><title xml:lang="en">Circadian variation in urinary excretion of bone collagen cross-links.</title><author><name sortKey="Bollen, A M" sort="Bollen, A M" uniqKey="Bollen A" first="A M" last="Bollen">A M Bollen</name><affiliation wicri:level="4"><nlm:affiliation>Department of orthopaedics, University of Washington, Seattle, USA.</nlm:affiliation><country xml:lang="fr">États-Unis</country><wicri:regionArea>Department of orthopaedics, University of Washington, Seattle</wicri:regionArea><orgName type="university">Université de Washington</orgName><placeName><settlement type="city">Seattle</settlement><region type="state">Washington (État)</region></placeName></affiliation></author><author><name sortKey="Martin, M D" sort="Martin, M D" uniqKey="Martin M" first="M D" last="Martin">M D Martin</name></author><author><name sortKey="Leroux, B G" sort="Leroux, B G" uniqKey="Leroux B" first="B G" last="Leroux">B G Leroux</name></author><author><name sortKey="Eyre, D R" sort="Eyre, D R" uniqKey="Eyre D" first="D R" last="Eyre">D R Eyre</name></author></analytic><series><title level="j">Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research</title><idno type="ISSN">0884-0431</idno><imprint><date when="1995" type="published">1995</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Adult (MeSH)</term><term>Aged (MeSH)</term><term>Bone Resorption (diagnosis)</term><term>Bone Resorption (urine)</term><term>Circadian Rhythm (MeSH)</term><term>Collagen (urine)</term><term>Collagen Type I (MeSH)</term><term>Creatinine (urine)</term><term>Female (MeSH)</term><term>Humans (MeSH)</term><term>Immunoassay (MeSH)</term><term>Male (MeSH)</term><term>Middle Aged (MeSH)</term><term>Peptides (urine)</term></keywords><keywords scheme="KwdFr" xml:lang="fr"><term>Adulte (MeSH)</term><term>Adulte d'âge moyen (MeSH)</term><term>Collagène (urine)</term><term>Collagène de type I (MeSH)</term><term>Créatinine (urine)</term><term>Dosage immunologique (MeSH)</term><term>Femelle (MeSH)</term><term>Humains (MeSH)</term><term>Mâle (MeSH)</term><term>Peptides (urine)</term><term>Rythme circadien (MeSH)</term><term>Résorption osseuse (diagnostic)</term><term>Résorption osseuse (urine)</term><term>Sujet âgé (MeSH)</term></keywords><keywords scheme="MESH" type="chemical" qualifier="urine" xml:lang="en"><term>Collagen</term><term>Creatinine</term><term>Peptides</term></keywords><keywords scheme="MESH" qualifier="diagnosis" xml:lang="en"><term>Bone Resorption</term></keywords><keywords scheme="MESH" qualifier="diagnostic" xml:lang="fr"><term>Résorption osseuse</term></keywords><keywords scheme="MESH" qualifier="urine" xml:lang="en"><term>Bone Resorption</term></keywords><keywords scheme="MESH" xml:lang="en"><term>Adult</term><term>Aged</term><term>Circadian Rhythm</term><term>Collagen Type I</term><term>Female</term><term>Humans</term><term>Immunoassay</term><term>Male</term><term>Middle Aged</term></keywords><keywords scheme="MESH" qualifier="urine" xml:lang="fr"><term>Adulte</term><term>Adulte d'âge moyen</term><term>Collagène</term><term>Collagène de type I</term><term>Créatinine</term><term>Dosage immunologique</term><term>Femelle</term><term>Humains</term><term>Mâle</term><term>Peptides</term><term>Rythme circadien</term><term>Résorption osseuse</term><term>Sujet âgé</term></keywords></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">Bone resorption can be evaluated by measuring the urinary excretion of collagen type I cross-linked N telopeptides (NTx). Since it is difficult to obtain (and verify) 24 h urine collections from patients, untimed spot urines are more practical. Such measurements, however, need correction for urine dilution and potentially may vary with collection time since a circadian rhythm in bone metabolism has been reported. This study examined cross-link excretion in urine voids serially collected during a 24 h period from subjects living their normal daily routine (as opposed to a controlled hospital setting). This mimics the situation for walk-in patients visiting a clinician and providing a spot urine. A total of 35 dentists (20 males, 15 females) collected all urine voids separately over a 24 h period. Urines were analyzed for creatinine and NTx. The effects of time of day on the excretion rates of these metabolites (in nmol/h) and on the cross-link:creatinine ratio were assessed. A circadian rhythm was evident in the excretion rate of creatinine with a peak in the late afternoon (18% higher than the 24 h mean, p = 0.0004). The NTx excretion rate peaked in the morning (9% higher than the 24 h mean) but this latter rhythm was not statistically significant (p = 0.31). The NTx:creatinine ratio fell during the day from a high (122% of the 24 h mean) in the early morning to a low in the early evening. This rhythm in the NTx:creatinine ratio in untimed spot urines was statistically significant (p < 0.0001). In conclusion, the NTx:creatinine ratio in spot urines from adult outpatient subjects showed a significant circadian rhythm. Variations in creatinine excretion were the primary cause. Time of day should, therefore, be taken into account when comparing test results of spot urines with normal ranges or with other samples from the same subject.</div></front></TEI><pubmed><MedlineCitation Status="MEDLINE" Owner="NLM"><PMID Version="1">8619368</PMID><DateCompleted><Year>1996</Year><Month>06</Month><Day>07</Day></DateCompleted><DateRevised><Year>2016</Year><Month>10</Month><Day>19</Day></DateRevised><Article PubModel="Print"><Journal><ISSN IssnType="Print">0884-0431</ISSN><JournalIssue CitedMedium="Print"><Volume>10</Volume><Issue>12</Issue><PubDate><Year>1995</Year><Month>Dec</Month></PubDate></JournalIssue><Title>Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research</Title><ISOAbbreviation>J Bone Miner Res</ISOAbbreviation></Journal><ArticleTitle>Circadian variation in urinary excretion of bone collagen cross-links.</ArticleTitle><Pagination><MedlinePgn>1885-90</MedlinePgn></Pagination><Abstract><AbstractText>Bone resorption can be evaluated by measuring the urinary excretion of collagen type I cross-linked N telopeptides (NTx). Since it is difficult to obtain (and verify) 24 h urine collections from patients, untimed spot urines are more practical. Such measurements, however, need correction for urine dilution and potentially may vary with collection time since a circadian rhythm in bone metabolism has been reported. This study examined cross-link excretion in urine voids serially collected during a 24 h period from subjects living their normal daily routine (as opposed to a controlled hospital setting). This mimics the situation for walk-in patients visiting a clinician and providing a spot urine. A total of 35 dentists (20 males, 15 females) collected all urine voids separately over a 24 h period. Urines were analyzed for creatinine and NTx. The effects of time of day on the excretion rates of these metabolites (in nmol/h) and on the cross-link:creatinine ratio were assessed. A circadian rhythm was evident in the excretion rate of creatinine with a peak in the late afternoon (18% higher than the 24 h mean, p = 0.0004). The NTx excretion rate peaked in the morning (9% higher than the 24 h mean) but this latter rhythm was not statistically significant (p = 0.31). The NTx:creatinine ratio fell during the day from a high (122% of the 24 h mean) in the early morning to a low in the early evening. This rhythm in the NTx:creatinine ratio in untimed spot urines was statistically significant (p < 0.0001). In conclusion, the NTx:creatinine ratio in spot urines from adult outpatient subjects showed a significant circadian rhythm. Variations in creatinine excretion were the primary cause. Time of day should, therefore, be taken into account when comparing test results of spot urines with normal ranges or with other samples from the same subject.</AbstractText></Abstract><AuthorList CompleteYN="Y"><Author ValidYN="Y"><LastName>Bollen</LastName><ForeName>A M</ForeName><Initials>AM</Initials><AffiliationInfo><Affiliation>Department of orthopaedics, University of Washington, Seattle, USA.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Martin</LastName><ForeName>M D</ForeName><Initials>MD</Initials></Author><Author ValidYN="Y"><LastName>Leroux</LastName><ForeName>B G</ForeName><Initials>BG</Initials></Author><Author ValidYN="Y"><LastName>Eyre</LastName><ForeName>D R</ForeName><Initials>DR</Initials></Author></AuthorList><Language>eng</Language><GrantList CompleteYN="Y"><Grant><GrantID>R01 AR036794</GrantID><Acronym>AR</Acronym><Agency>NIAMS NIH HHS</Agency><Country>United States</Country></Grant><Grant><GrantID>R37 AR037318</GrantID><Acronym>AR</Acronym><Agency>NIAMS NIH HHS</Agency><Country>United States</Country></Grant><Grant><GrantID>1P30DE09743</GrantID><Acronym>DE</Acronym><Agency>NIDCR NIH HHS</Agency><Country>United States</Country></Grant><Grant><GrantID>1R29DE10052</GrantID><Acronym>DE</Acronym><Agency>NIDCR NIH HHS</Agency><Country>United States</Country></Grant></GrantList><PublicationTypeList><PublicationType UI="D016428">Journal Article</PublicationType><PublicationType UI="D013485">Research Support, Non-U.S. Gov't</PublicationType><PublicationType UI="D013487">Research Support, U.S. Gov't, P.H.S.</PublicationType></PublicationTypeList></Article><MedlineJournalInfo><Country>United States</Country><MedlineTA>J Bone Miner Res</MedlineTA><NlmUniqueID>8610640</NlmUniqueID><ISSNLinking>0884-0431</ISSNLinking></MedlineJournalInfo><ChemicalList><Chemical><RegistryNumber>0</RegistryNumber><NameOfSubstance UI="D024042">Collagen Type I</NameOfSubstance></Chemical><Chemical><RegistryNumber>0</RegistryNumber><NameOfSubstance UI="D010455">Peptides</NameOfSubstance></Chemical><Chemical><RegistryNumber>0</RegistryNumber><NameOfSubstance UI="C052929">collagen type I trimeric cross-linked peptide</NameOfSubstance></Chemical><Chemical><RegistryNumber>9007-34-5</RegistryNumber><NameOfSubstance UI="D003094">Collagen</NameOfSubstance></Chemical><Chemical><RegistryNumber>AYI8EX34EU</RegistryNumber><NameOfSubstance UI="D003404">Creatinine</NameOfSubstance></Chemical></ChemicalList><CitationSubset>IM</CitationSubset><MeshHeadingList><MeshHeading><DescriptorName UI="D000328" MajorTopicYN="N">Adult</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D000368" MajorTopicYN="N">Aged</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D001862" MajorTopicYN="N">Bone Resorption</DescriptorName><QualifierName UI="Q000175" MajorTopicYN="N">diagnosis</QualifierName><QualifierName UI="Q000652" MajorTopicYN="Y">urine</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D002940" MajorTopicYN="Y">Circadian Rhythm</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D003094" MajorTopicYN="N">Collagen</DescriptorName><QualifierName UI="Q000652" MajorTopicYN="Y">urine</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D024042" MajorTopicYN="N">Collagen Type I</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D003404" MajorTopicYN="N">Creatinine</DescriptorName><QualifierName UI="Q000652" MajorTopicYN="N">urine</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D005260" MajorTopicYN="N">Female</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D006801" MajorTopicYN="N">Humans</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D007118" MajorTopicYN="N">Immunoassay</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D008297" MajorTopicYN="N">Male</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D008875" MajorTopicYN="N">Middle Aged</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D010455" MajorTopicYN="N">Peptides</DescriptorName><QualifierName UI="Q000652" MajorTopicYN="Y">urine</QualifierName></MeshHeading></MeshHeadingList></MedlineCitation><PubmedData><History><PubMedPubDate PubStatus="pubmed"><Year>1995</Year><Month>12</Month><Day>1</Day></PubMedPubDate><PubMedPubDate PubStatus="medline"><Year>1995</Year><Month>12</Month><Day>1</Day><Hour>0</Hour><Minute>1</Minute></PubMedPubDate><PubMedPubDate PubStatus="entrez"><Year>1995</Year><Month>12</Month><Day>1</Day><Hour>0</Hour><Minute>0</Minute></PubMedPubDate></History><PublicationStatus>ppublish</PublicationStatus><ArticleIdList><ArticleId IdType="pubmed">8619368</ArticleId><ArticleId IdType="doi">10.1002/jbmr.5650101207</ArticleId></ArticleIdList></PubmedData></pubmed><affiliations><list><country><li>États-Unis</li></country><region><li>Washington (État)</li></region><settlement><li>Seattle</li></settlement><orgName><li>Université de Washington</li></orgName></list><tree><noCountry><name sortKey="Eyre, D R" sort="Eyre, D R" uniqKey="Eyre D" first="D R" last="Eyre">D R Eyre</name><name sortKey="Leroux, B G" sort="Leroux, B G" uniqKey="Leroux B" first="B G" last="Leroux">B G Leroux</name><name sortKey="Martin, M D" sort="Martin, M D" uniqKey="Martin M" first="M D" last="Martin">M D Martin</name></noCountry><country name="États-Unis"><region name="Washington (État)"><name sortKey="Bollen, A M" sort="Bollen, A M" uniqKey="Bollen A" first="A M" last="Bollen">A M Bollen</name></region></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
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